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Do Large Clinical Trials Adequately Consider Individual Patient Physiology? Debating The RELIEF Study

By Michael Keane, BMBS, FANZCA and Shashikanth Manikappa, MD, DNB, FANZCA
February 21, 2019

Patient safety requires a well-informed debate about the rationale of large, randomized controlled trials (RCTs) and whether, by their very nature, they can adequately consider the unique physiology of every individual patient. 

NEW Ultraspire Lumen 170 Green Waist Mounted Belt Light for Running TriathlonNEW Velocity A-23 700C 32H RimNew Vintage Selle San Marco Concor Supercorsa brown leather saddle  Continue reading “Do Large Clinical Trials Adequately Consider Individual Patient Physiology? Debating The RELIEF Study”

WAKE-UP Time for Thrombolysis in Acute Stroke?

NEW Schwalbe Durano DD Perf SS RG 700x28 Road Tire

By Martina McGrath, MD
October 30, 2018

MRI thrombolysis for stroke of unknown time of onset

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Prior studies have suggested a particular pattern may be seen on an MRI of the brain in the early hours following stroke onset; a visible ischemic lesion on diffusion-weighted imaging along with the lack of a hyperintense signal in the same area on fluid-attenuated inversion recovery (FLAIR). The benefit of aggressive stroke intervention in patients with the combination of unknown time of symptom onset and this particular signal mismatch on MRI brain scans is unknown. Continue reading “WAKE-UP Time for Thrombolysis in Acute Stroke?”

NEW Schwalbe One V-Guard 700x23 Road Tire

By Olivier Lucar
October 16, 2018

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NEW Selle Royal Drifter Gel Saddle Xsenium

By Connor Emdin
September 26, 2018

NEW Zipp 30 Course Clincher Rear Wheel Disc Brake SRAM XD-R DriverNEW ZONE MIRAGE LONG SLEEVE SLEEVELESS LEOTARD DANCE GYMNASTICS GYM SIZE 24-38NEW Avid XO MTB Bicycle Hydraulic Disc Brakeset 850 1800mm Hoses w redorsNEW Ceramic Bearings -- Trek BB90 Shimano 10 11 Speed Cranksets Continue reading “Use of Guideline-Recommended Medical Therapy in Patients with Heart Failure”

Restrictive versus Liberal Fluid Therapy in Abdominal Surgery

By Connor Emdin
August 28, 2018

NEW Grey [L] NIKE PRO Women's Hyperwarm 3.0 DRI-FIT Pants-Tights LargeNew Maxxis Ikon Folding Mountain Bicycle Tire Pair 29 x 2.00 (3C MAXX TR)NEW Stan's NoTubes 3.30 RD Road Bicycle Hub (Rear) Disc Brake 11s Shimano SRAMNEW Adult Medium Red Triumph Gymnastics Comp Leotard by Snowflake Designs Continue reading “Restrictive versus Liberal Fluid Therapy in Abdominal Surgery”

Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?

By Martina McGrath, MD
August 8, 2018

It is estimated that 1 in every 7.5 people in the US will die of sudden cardiac death.NEW Shimano BR-5600 Rear Brake 105 Survival following out-of-hospital cardiac arrest has increased in recent years, from 10.2% in 2006, to 12.4% in 2015.1 However, only 9% of those surviving to hospital discharge were classified as having good functional status. Therefore, significant long-term neurologic impairment is a common outcome of cardiac arrest. Continue reading “Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?”

Cervical Cancer Screening Using HPV Testing Alone: Are We There Yet?

New Shimano Dura-Ace HB-7710-R 120 x 164mm Axle NUT Type 28H Front Hub

By Martina McGrath, MD
July 18, 2018

NEW Patriot Biketard by Snowflake DesignsNew. 20 ;451 ISO Front Sun Assault Rim;Shimano-RS-400 HubNewton Kismet II Womens Running shoes Sz 8.5 Neon Pink MSRP 135NF Rechargeable Bike Light a powerful lighting unit NEW Shimano HG500 10-Speed 11-25t Cassette

New Race TT 27.5 x 2.0 Tire Folding 60tpi Dual Compound Tubeless Ready Maxxis nfeovd1827-Tires

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New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is ... Read moreabout the condition








Dulaglutide in Type 2 Diabetes: Do GLP-1 agonists delay progression of diabetic nephropathy?

New Shimano SLX FD-M660-10 MTB Bike Triple Front Derailleur Dyna-Sys 31.8 34.9mm

By Connor Emdin
June 27, 2018

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Procalcitonin-Guided Antibiotic Therapy in Lower Respiratory Tract Infection: Is It Safe?

New Shimano Ultegra FD-R8000-F Front Derailleur

By Martina McGrath, MD
June 5, 2018


New Shimano XTR CN-HG900-11-speed Mountain Bicycle Chain 116 links w pins

NIKE Free Tr 7 Womens Cross Training shoes

By Lea Borgi, MD
May 16, 2018

NIKE Men's Air Huarache Running shoesNIKE Mens M NSW CRW AIR MAX 861582NIKE PRO Fierce Medium Support Training Sports Bra 620279 Crimson Purple SMALL Continue reading “Does Menu Labeling Lead to Healthier Food Choices?”